Liposarcoma

This tumour originates in the fat cells (adipocytes) of the body. It is among the most common subtypes of sarcoma, accounting for approximately 20% of all soft tissue sarcomas. Liposarcomas can occur in various locations throughout the body, but they predominantly develop in the limbs — particularly the thighs — and in the retroperitoneal space (the area behind the abdominal cavity).

There are different subtypes of liposarcoma, each with distinct characteristics:

• Well-differentiated liposarcoma: tends to have a more favourable prognosis and may resemble normal fat cells. It usually grows slowly and forms large, bulky masses.
• Dedifferentiated liposarcoma: contains a mix of more aggressive tumour cells that lack the typical features of the well-differentiated form. It can be more challenging to treat and has a higher likelihood of metastasis.
• Myxoid or round cell liposarcoma: made up of tumour cells with a round appearance that produce a gelatinous substance. It is known for a high rate of recurrence and the potential to metastasise to other parts of the body.